Chemical Analysis of Surfaces Using Alpha Particles

Chemical analysis of surfaces using alpha particle interactions in instruments incorporating curium 242 alpha sources and semiconductor silicon detector

Mechanisms of superconductivity investigated by nuclear radiation

Investigation focused on the behavior of superconducting magnet and its constituent materials during and after exposure to nuclear radiation. The results will indicate the feasibility of their use in diverse applications and various environments

The chemical analysis experiment for the Surveyor lunar mission

Alpha particle detector experiment for chemical analysis of lunar surface by Surveyor spacecraf

Upland Cotton Variety Tests 1961

This item is part of the Agricultural Experiment Station archive. It was digitized from a physical copy provided by the University Libraries at the University of Arizona. For more information, please email CALS Publications at [email protected]

Alpha radioactivity of the lunar surface at the Surveyor 5, 6, and 7 landing sites

Alpha radioactivity of lunar surface at Surveyor 5, 6, and 7 landing site

The Lawyer and the Private Legal Process

Private law--particular rules created for and applied to particular individuals to govern their relationships with each other--is a marked characteristic of society. People in a nation of free enterprise with a developing, malleable economy must have the freedom and the power to shape their legal relations with one another through the use of rules of law suited to their goals. Most of this law--contracts, wills, and trusts--has only temporary effect. The terms are limited, and all of it is for a private, rather than a public purpose. The limited scope of private law, however, is not a good measure of its influence. The private legal process as a part of our system of jurisprudence makes a great contribution to the social life. Many new forms of legal relations trace their origins not to the courts or to the legislature, but to a new kind of instrument first created in the lawyer\u27s office

High Speed Photometry of SDSS J013701.06-091234.9

We present high speed photometry of the Sloan Digital Sky Survey cataclysmic variable SDSS J013701.06-091234.9 in quiescence and during its 2003 December superoutburst. The orbital modulation at 79.71\pm0.01 min is double humped; the superhump period is 81.702\pm0.007 min. Towards the end of the outburst late superhumps with a period of 81.29\pm0.01 min were observed. We argue that this is a system of very low mass transfer rate, and that it probably has a long outburst interval.Comment: 5 pages, 8 figures. Accepted for publication in MNRA

Intrabodies Binding the Proline-Rich Domains of Mutant Huntingtin Increase Its Turnover and Reduce Neurotoxicity

Although expanded polyglutamine (polyQ) repeats are inherently toxic, causing at least nine neurodegenerative diseases, the protein context determines which neurons are affected. The polyQ expansion that causes Huntington's disease (HD) is in the first exon (HDx-1) of huntingtin (Htt). However, other parts of the protein, including the 17 N-terminal amino acids and two proline (polyP) repeat domains, regulate the toxicity of mutant Htt. The role of the P-rich domain that is flanked by the polyP domains has not been explored. Using highly specific intracellular antibodies (intrabodies), we tested various epitopes for their roles in HDx-1 toxicity, aggregation, localization, and turnover. Three domains in the P-rich region (PRR) of HDx-1 are defined by intrabodies: MW7 binds the two polyP domains, and Happ1 and Happ3, two new intrabodies, bind the unique, P-rich epitope located between the two polyP epitopes. We find that the PRR-binding intrabodies, as well as VL12.3, which binds the N-terminal 17 aa, decrease the toxicity and aggregation of HDx-1, but they do so by different mechanisms. The PRR-binding intrabodies have no effect on Htt localization, but they cause a significant increase in the turnover rate of mutant Htt, which VL12.3 does not change. In contrast, expression of VL12.3 increases nuclear Htt. We propose that the PRR of mutant Htt regulates its stability, and that compromising this pathogenic epitope by intrabody binding represents a novel therapeutic strategy for treating HD. We also note that intrabody binding represents a powerful tool for determining the function of protein epitopes in living cells

RAID-2: Design and implementation of a large scale disk array controller

We describe the implementation of a large scale disk array controller and subsystem incorporating over 100 high performance 3.5 inch disk drives. It is designed to provide 40 MB/s sustained performance and 40 GB capacity in three 19 inch racks. The array controller forms an integral part of a file server that attaches to a Gb/s local area network. The controller implements a high bandwidth interconnect between an interleaved memory, an XOR calculation engine, the network interface (HIPPI), and the disk interfaces (SCSI). The system is now functionally operational, and we are tuning its performance. We review the design decisions, history, and lessons learned from this three year university implementation effort to construct a truly large scale system assembly